蔡鹏
个人简历
2007-2011 南京林业大学 学士学位
2011-2014 南京林业大学 硕士学位
2014-2017 上海交通大学 博士研究生
2017-2018 浙江大学 化学工程与生物工程学院 科研助理
2018-2022 大连化学物理研究所与大连理工大学 联合培养 博士学位
2022-2025 大连化物所生物技术部1823组 博士后
研究方向：甲醇的高效生物转化及酵母合成生物学方法的开发
代表文章
1. Bai F., Cai P., Yao L., Shen Y.W., Li Y.X., Zhou Y.J.*, Inducible regulating homologous recombination enables precise genome editing in Pichia pastoris without perturbing cellular fitness, Trends Biotechnol., 2025, 43(6), 1385-1402.
2. Wu X.Y., Ren Y.Y., Chen S.S., Cai P.*, Zhou Y.J., Production of L-lactic acid from methanol by engineered yeast Pichia pastoris. Bioresour. Technol., 2025, 415, 131730.
3. Chen S.S., Zhang M.Y., Wu X.Y., Bai F., Gao L.H., Shen Y.W., Dou S.H.*, Cai P.*, Zhou Y.J., Promoter engineering for enhanced 3-hydroxypropionic acid production in Pichia pastoris, Synth. Syst. Biotechnol. 2025, 10, 916-924.
4. Ren Y.Y., Celińska E., Cai P.*, Zhou Y.J.*, Combing Directed Enzyme Evolution with Metabolic Engineering to Develop Efficient Microbial Cell Factories. Chem. & Bio. Engineering, 2025, doi.org/10.1021/cbe.5c00002.
5. Zhang H.Y., Cai P., Guo J., Gao J.Q., Xie L.F., Su P., Zhai X.X., Jin B.L., Cui G.H.*, Zhou Y. J.*, Huang L.Q.*, Engineering cellular dephosphorylation boosts (+)-borneol production in yeast, Acta Pharmaceutica Sinica B., 2025, 15(2), 1171-1182.
6. Gao L.H.#, Hou R.#, Cai P., Yao L., Wu X.Y., Li Y.X., Zhang L.H.*, Zhou Y.J.*, Engineering Yeast Peroxisomes for α-Bisabolene Production from Sole Methanol with the Aid of Proteomic Analysis, JACS Au, 2024, 4(7), 2474-2483.
7. Shen Y.W., Cai P., Gao L.H., Wu X.Y., Yao L., Zhou Y.J.*, Engineering high production of fatty alcohols from methanol by constructing coordinated dual biosynthetic pathways, Bioresour. Technol., 2024, 412, 131396.
8. Gao L.H., Zhang K., Shen Y.W., Cai P.*, Zhou Y.J.*, Engineering a versatile yeast platform for sesquiterpene production from glucose or methanol, Biotechnol. J., 2024, 19, 2400261.
9. 蔡鹏, 吴晓燕, 解林峰, 申益维, 高琳惠, 周雍进*, 甲醇微生物转化最新进展. 中国科学：化学, 2024, 54(11), 2199-2218.
10. 张梦瑶，蔡鹏，周雍进*，合成生物学助力萜类香精香料可持续生产, 合成生物学, 2024, DOI: 10.12211/2096-8280.2024-057.
11. Wu X.Y., Cai P., Yao L., Zhou Y.J.*, Genetic tools for metabolic engineering of Pichia pastoris, Eng. Microbiol., 2023, 3, 100094.
12. Qiao S.J., Bai F., Cai P., Zhou Y.J., Yao L.*, An improved CRISPRi system in Pichia pastoris, Synth. Syst. Biotechnol., 2023, 8, 479-485.
13. Wu X.Y., Cai P., Gao L.H., Li Y.X., Yao L., Zhou Y.J.*, Efficient bioproduction of 3‑hydroxypropionic acid from methanol by a synthetic yeast cell factory, ACS Sustainable Chem. Eng., 2023, 11, 6445-6453.
14. Cai P., Wu X.Y., Deng J., Gao L.H., Shen Y.W., Yao L., Zhou Y.J.*, Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris, Proc. Natl. Acad. Sci. USA, 2022, 119(29), e2201711119.
15. Cai P., Li Y.X., Zhai X.X., Yao L., Ma X.J., Jia L.Y., Zhou Y.J.*, Microbial synthesis of long‑chain α‑alkenes from methanol by engineering Pichia pastoris, Bioresour. Bioprocess., 2022, 9, 58. (Featured article)
16. Zhang K., Duan X.P., Cai P.，Gao L.H., Wu X.Y., Yao L., Zhou Y.J.*, Fusing an exonuclease with Cas9 enhances homologous recombination in Pichia pastoris, Microb. Cell Fact., 2022, 21, 182.
17. Cai P.#, Duan X.P.#, Wu X.Y., Gao L.H., Ye M., Zhou Y.J.*, Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia Pastoris, Nucleic Acids Res., 2021, 49(13), 7791-7805.
18. Cai P., Gao J.Q., Zhou Y.J.*, CRISPR-mediated genome editing in non-conventional yeasts for biotechnological applications, Microb. Cell Fact., 2019, 18, 63.
出站去向：大连化物所生物技术部1823组
