Xuan Cao   

Education Experience

2008-2012 East China University of Science and Technology  Bachelor

2012-2017 East China University of Science and Technology  Doctor

2017-2022 DICP CAS  Postdoctor

Research Interest

Metabolic engineering of Saccharomyces cerevisiae

Featured Publications

1. Cao X., Yu W., Chen Y., Yang S., Zhao Z.K., Nielsen J., Luan H.W., Zhou Y.J.*, Engineering yeast for high-level production of diterpenoid sclareol, Metab. Eng., 2023, 75, 19-28.

2. Cao C.Y., Zhang H.Y., Cao X., Kong S.J., Zhu B.W., Lin X.P*., Zhou Y.J.*, Construction and optimization of nonclassical Isoprenoid biosynthetic pathways in yeast peroxisomes for (+)-valencene production, 2023, J. Agric. Food Chem., 2023, 71, 11124-11130.

3. Yu W., Cao X., Gao J. ., Zhou Y.J.*, Overproduction of 3-hydroxypropionate in a super yeast chassis, Bioresource Technol., 2022, 361, 127690.

4. Cao C.Y., Cao X., Yu W.,  Chen Y.X., Lin X.P., Zhu B.W.*, Zhou Y.J.*, Global metabolic rewiring of yeast enables overproduction of  sesquiterpene (+)-valencene, J. Agric. Food Chem., 2022, 70(23), 7180-7187.

5. Wei L.J.#, Cao X.#, Liu, J.J., Kwak S., Jin Y.S., Wang W., Hua Q.*, Increased accumulation of squalene in engineered Yarrowia lipolytica through deletion of PEX10 and URE2. Appl Environ Microbiol., 2021, 87(17), e0048121.

6. Cao X., Yang S., Cao C., Zhou Y.J.*, Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast, Synth. Syst. Biotechnol., 2020, 5, 179-186.

7. Yang S., Cao X., Yu W., Li S., Zhou Y.J.*, Efficient targeted mutation of genomic essential genes in yeast Saccharomyces  cerevisiae, Appl. Microbial. Biotechnol., 2020, 104, 3037-3047.

8. Gao Q., Cao X., Huang Y.Y., Yang J.L., Chen J., Wei L.J.*, Hua Q.*, Overproduction of fatty acid ethyl esters by the oleaginous yeast Yarrowia lipolytica through metabolic engineering and process optimization, ACS Synth. Biol., 2018, 7(5), 1371-1380.

9. Cao X.#, Wei L.J.#, Lin J.Y., Hua Q.*, Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica, Bioresource Technol., 2017, 245, 1641-1644.

10. Cao X., Lv Y.B., Chen J., Imanaka T., Wei L.J.*, Hua Q.*, Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction, Biotechnol. Biofuels, 2016, 9(1), 214.

Current position

Jinan Microecological Biomedicine Shandong Laboratory