Xueying Wang Associate Professor
Education and Working Experience
2006-2010 Dalian University Bachelor
2010-2018 DICP CAS Doctor
2018-2021 DICP CAS Assistant Professor
2021-Now DICP CAS Associate Professor
Research Interest
Yeast cell factory construction and methanol biotransformation
Tel: 0411-84379066
Featured Publications
1. Wu Y.J., Wang X.Y., Yang K.G., Sui Z.G.*, Yan H.M.*, Zhang L.H., Zhang Y.K., Automated strain-to-peptide conversion: a high-throughput proteome analysis platform empowering rational design of microbial cell factories, Bioresour. Technol., 2026, 444, 134010.
2. Wu X.H., Hu Y.H., Huang Y.Z., Zhang L.Y., Xue Y., Cao H.L., Wang X.Y.*, Zhou Y.J., Expanding the Cofactor Range of Aldehyde Reductase YqhD by Mutating Key Amino Acids, Biotechnol Lett, 2026, doi.org/10.1007/s10529-026-03747-z.
3. Wang X.Y.*, Liu Y.Y., Hu Y.H., Huang Y.Z., Zhang L.Y., Xue H.Z., Zhou Y.J., Zhao Z.K.*, Engineering nicotinamide adenine dinucleotide oxidase for regeneration of oxidized non-natural cofactor, ChemBioChem, 2025, 26, e202500254.
4. Hu Y.H., Wang X.Y., Huang Y.Z., Guo X.J., Xue H.Z., Martin P., Bernd N., Zhao Z.K.*, Enzymatic synthesis and characterization of nicotinamide riboside pseudouridine diphosphate, Tetrahedron Lett., 2025, 155, 155432.
5. Wang X.Y., Zhou Y.J., Zhao Z.K.*, Non-natural redox cofactors empowered biomanufacturing, CIESC J., 2024, 75(11), 4037-4047 (in Chinese).
6. Guo X.J., Wang X.Y., Hu Y.H., Zhang L.Y., Zhao Z.K.*, Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide, Sci. Rep., 2024, 14, 28701.
7. Wang J.T., Wan L., Guo X.J., Wang X.Y.*, Zhao Z.K., Competitive inhibition of a non-natural cofactor dependent formaldehyde dehydrogenase by imidazole, Biotechnol. Lett., 2023, 45, 679–687.
8. Fu K.X., Wang X.Y., Huang Y.Z., Xue H.Z., Hu Y.H., Zhao Z.K.*, Rational design-based improvement of 1,3-propanediol oxidoreductase stability and activity, Food and Fermentation Ind., 2023, 49(16), 18-25 (in Chinese).
9. Li Q., Guo X.J., Wang X.Y., Wang J.T., Wan L., Xue H.Z., Zhao Z.K*., Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation, J. Energy Chem., 2023, 79, 31–36.
10. Wan L., Wang X.Y.*, Hu Y.H., Li Q., Zhao Z.K., Gram-scale biocatalytic preparation of the non-natural cofactor nicotinamide cytosine dinucleotide, Tetrahedron Lett., 2022, 88, 153368.
11. Wang X.Y., Feng Y.B., Guo X.J., Wang Q., Ning S.Y., Li Q., Wang J.T., Wang L., Zhao Z.K*, Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide, Nat. Commun. 2021, 12(1), 2116.
12. Guo X.J., Liu Y.X., Wang Q., Wang X.Y., Li Q., Liu W.J., Zhao Z.K*, Non-natural cofactor and formate-driven reductive carboxylation of pyruvate, Angew. Chem. Int. Ed., 2020, 59(8), 3143–3146.
13. Guo X.J., Wang X.Y., Liu Y.X., Li Q., Wang J.T., Liu W.J.*, Zhao Z.K*, Structure-guided design of formate dehydrogenase for regeneration of a non-natural redox cofactor, Chem. Eur. J., 2020, 26(70), 16611–16615.
14. Liu Y.X., Feng Y.B., Wang L., Guo X.J., Liu W.J., Li Q., Wang X.Y., Xue S.*, Zhao Z.K*., Structural insights into phosphite dehydrogenase variants favoring a non-natural redox cofactor, ACS Catal., 2019, 9, 1883–1887.
15. Wang X.Y., Wang L., Lin X.P., Yang X.B., Liu W.J., Zhao Z.K*, Visualizing soluble protein mutants by using monomeric red fluorescent protein as a reporter for directed evolution, Appl Biochem Biotechnol., 2018, 185(1), 81-90.
16. Wang X.Y., Zhou Y.J., Wang L., Liu W.J., Peng C., Zhao Z.K*, Engineering Escherichia coli nicotinic acid mononucleotide adenylyltransferase for fully active amidated NAD biosynthesis, Appl Environ Microbiol. 2017, 81(13), e00692-17.
