课题组成员

周雍进

研究组长CV

周雍进,博士,研究员,博士生导师,研究组组长,张大煜优秀学者,国家自然科学基金委杰出青年基金项目获得者(2024)、国家自然科学基金委优秀青年基金项目获得者(2019)、国家引进人才青年项目入选者(2018)以及中科院人才计划入选者(2017)。曾于江南大学获得食品科学与工程学士学位(2006);天津大学获得生物化工硕士学位(2008);大连化学物理研究所获得生物化工博士学位(2012);2012-2016年在瑞典查尔姆斯理工大学从事博士后研究。2017年1月回到中科院大连化物所组建合成生物学与生物催化课题创新特区研究组,受聘为课题组长,2022年转为正式研究组序列,更名合成微生物学研究组。曾在Cell, Nature Energy, Nature Metabolism, Nature Chemical Biology, Nature Communications, JACS, PNAS等期刊发表论文100余篇,被引用7000余次。曾获得中国药学会科学技术奖一等奖(2015),国际代谢科学会议青年科学家奖(2016), ‘伦世仪’基金会杰出青年学者奖(2018),全国生物技术创新大会“最具发展潜力奖”(2019)以及安捷伦“ACT-UR”研究科学奖(2023)。目前担任Biotechnology Journal主编,Synthetic and Systems BiotechnologyBioDesign Research副主编,FEMS Yeast Research等多个学术期刊编委

代表文章

1. Chen R.B., Chen X., Chen Y., Yang J., Chen W.*, Zhou Y. J.*, Zhang L.*, De novo biosynthesis of plant lignans by synthetic yeast consortia. Nat. Chem. Biol., 2025, Accepted.

2. Yang S., Chen R.B., Cao X., Wang G.D., Zhou Y.J.*, De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast, Nat. Commun., 2024, 15, 253.

3. Gao J.Q.#, Yu W.#, Li Y.X., Jin M.J., Yao L., Zhou Y.J.*, Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose, Nat. Chem. Biol., 2023, 19, 1524-1531. (Cover)

4. Zhai X.X., Gao J.Q., Li Y.X., Grininger M., Zhou Y.J.*,  Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast, Proc. Natl. Acad. Sci. USA, 2023, 120(12), e2220816120.

5. Gao J.Q., Li Y.X., Yu W., Zhou Y.J.*, Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol, Nat. Metab., 2022, 4, 932-943.

6. Chen R.B., Gao J.Q., Yu W., Chen X.H., Zhai X.X., Chen Y., Zhang L.*, Zhou Y.J.*, Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast, Nat. Chem. Biol., 2022, 18, 520-529.

7. Cai P., Wu X.Y., Deng J., Gao L.H., Shen Y.W., Yao L., Zhou Y.J.*, Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris, Proc. Natl. Acad. Sci. USA, 2022, 119(29), e2201711119.

8. Cai P.#, Duan X.P.#, Wu X.Y., Gao L.H., Ye M., Zhou Y.J.*, Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia Pastoris, Nucleic Acids Res., 2021, 49(13), 7791-7805.

9. Yu T.#, Zhou Y.J.#, Huang M.T., Liu Q.L., Pereira R., David F., Nielsen J.*, Reprogramming yeast metabolism from alcoholic fermentation to lipogenesis, Cell, 2018, 174(6), 1549-1558.

10.  Zhou Y.J., Kerkhoven E., Nielsen J.*, Barriers and opportunities in bio-based production of hydrocarbons, Nat. Energy, 2018, 3, 925-935.