王雪颖 副研究员
个人简历
2006-2010 大连大学 学士学位
2010-2018 大连化学物理研究所 博士学位
2018-2021 大连化物所生物技术部1816组 助理研究员
2021-2023 大连化物所生物技术部1816组 副研究员
2023- 大连化物所生物技术部1823组 副研究员
研究方向：酵母细胞工厂的构建以及甲醇生物转化研究
电话：0411-84379066
电子邮箱：wangxueying@dicp.ac.cn
代表文章：
1. Wang X.Y.*, Liu Y.Y., Hu Y.H., Huang Y.Z., Zhang L.Y., Xue H.Z., Zhou Y.J., Zhao Z.K.*, Engineering nicotinamide adenine dinucleotide oxidase for regeneration of oxidized non-natural cofactor, ChemBioChem, 2025, 26, e202500254.
2. Hu Y.H., Wang X.Y., Huang Y.Z., Guo X.J., Xue H.Z., Martin P., Bernd N., Zhao Z.K.*, Enzymatic synthesis and characterization of nicotinamide riboside pseudouridine diphosphate, Tetrahedron Lett., 2025, 155, 155432.
3. 王雪颖，周雍进，赵宗保*，非天然氧化还原辅酶赋能生物制造，化工学报，2024, 75(11), 4037-4047.
4. Guo X.J., Wang X.Y., Hu Y.H., Zhang L.Y., Zhao Z.K.*, Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide, Sci. Rep., 2024, 14, 28701.
5. Wang J.T., Wan L., Guo X.J., Wang X.Y.*, Zhao Z.K., Competitive inhibition of a non-natural cofactor dependent formaldehyde dehydrogenase by imidazole, Biotechnol. Lett., 2023, 45, 679–687.
6. 付凯璇，王雪颖*，黄彦喆，薛海曌，胡英菡，赵宗保, 基于理性设计提高1,3-丙二醇氧化还原酶的稳定性和活性, 食品与发酵工业，2023, 49(16), 18–25.
7. Li Q., Guo X.J., Wang X.Y., Wang J.T., Wan L., Xue H.Z., Zhao Z.K*., Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation, J. Energy Chem., 2023, 79, 31–36.
8. Wan L., Wang X.Y.*, Hu Y.H., Li Q., Zhao Z.K., Gram-scale biocatalytic preparation of the non-natural cofactor nicotinamide cytosine dinucleotide, Tetrahedron Lett., 2022, 88, 153368.
9. Wang X.Y., Feng Y.B., Guo X.J., Wang Q., Ning S.Y., Li Q., Wang J.T., Wang L., Zhao Z.K*, Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide, Nat. Commun. 2021, 12(1), 2116.
10. Guo X.J., Liu Y.X., Wang Q., Wang X.Y., Li Q., Liu W.J., Zhao Z.K*, Non-natural cofactor and formate-driven reductive carboxylation of pyruvate, Angew. Chem. Int. Ed., 2020, 59(8), 3143–3146.
11. Guo X.J., Wang X.Y., Liu Y.X., Li Q., Wang J.T., Liu W.J.*, Zhao Z.K*, Structure-guided design of formate dehydrogenase for regeneration of a non-natural redox cofactor, Chem. Eur. J., 2020, 26(70), 16611–16615.
12. Liu Y.X., Feng Y.B., Wang L., Guo X.J., Liu W.J., Li Q., Wang X.Y., Xue S.*, Zhao Z.K*., Structural insights into phosphite dehydrogenase variants favoring a non-natural redox cofactor, ACS Catal., 2019, 9, 1883–1887.
13. Wang X.Y., Wang L., Lin X.P., Yang X.B., Liu W.J., Zhao Z.K*, Visualizing soluble protein mutants by using monomeric red fluorescent protein as a reporter for directed evolution, Appl Biochem Biotechnol., 2018, 185(1), 81-90.
14. Wang X.Y., Zhou Y.J., Wang L., Liu W.J., Peng C., Zhao Z.K*, Engineering Escherichia coli nicotinic acid mononucleotide adenylyltransferase for fully active amidated NAD biosynthesis, Appl Environ Microbiol. 2017, 81(13), e00692-17.
